The 2nd NUCLEI Workshop, organized by Cluster Mechatronik & Automation at New Elements GmbH in Nuremberg, Bavaria, gave occasion to discuss different methods and approaches in digital business models. Digitalization is on the march and is about to form our societies drastically in the years to come. Especially users of digitalized solutions in manufacturing and trade are increasingly affected by this dynamic. Many fear to miss out on this trend and lose their economic basis. While in Germany the focus is set primarily on the technology itself, US companies for example tend to combine the use of new technologies with new potential business models that can be developed in consecuence. Therefore, the topics of Customer Relation Management, Product Design, Innovation and Service Offerings become connected and create new forms of implementation and marketing strategies especially for the middle-sized sector.